Here's how a paper would look like with in-text citations and a reference list at the end of the document:
The opioid epidemic is a serious problem in the United States, responsible for over 700,000 deaths beginning in the 1990s with the rise of prescription opioids.1-2 The most recent increases in opioid overdoses have been attributed to illicitly-manufactured fentanyl,1 which can be found laced into substances such as heroin and cocaine.3
References
1. Understanding the epidemic. Centers for Disease Control and Prevention Web site. https://www.cdc.gov/drugoverdose/epidemic/index.html. Updated December 19, 2018. Accessed April 24, 2019.
2. Kolodny A, Courtwright DT, Hwang CS. The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction. Annu Rev Public Health. 2015;36():559-574. doi: 10.1146/annurev-publhealth-031914-122957.
3. Rudd RA, Aleshire N, Zibbell JE, Gladden RM. Increases in drug and opioid overdose deaths--United States, 2000-2014. MMWR Morb Mortal Wkly Rep. 2016;64(50-51):1378-1382. doi: 10.15585/mmwr.mm6450a3.